Francis Loth has contributed to the field of biofluids over the past two decades. His research has examined the contribution of hemodynamics forces in the development and progression of vascular disease. In addition, he conducted some of the early research in cerebrospinal fluid dynamics and its relationship to craniospinal disorders (Chiari malformation and syringomyelia).

At the University of Akron, he is Professor and F. Theodore Harrington Chair in the Department of Mechanical Engineering and the Executive Director of the Conquer Chiari Research Center. He is the current Chair of the ASME Bioengineering Fluids Committee.

Read: Dr. Loth Awarded $500,000 grant by National Institutes of Health (NIH).


  • Executive Director, Conquer Chiari Research Center
  • Director, Biofluids Laboratory at the University of Akron
  • Professor in the Departments of Mechanical and Biomedical Engineering



  • M.S., Ph.D. Mechanical Engineering
    Georgia Institute of Technology, 1990, 1993
  • M.S. Aerospace Engineering
    University of Cincinnati, 1988
  • B.S. Aerospace Engineering
    West Virginia University, 1984


Research Interests

  • Biofluid Mechanics of Craniospinal disorders
  • Cardiovascular Hemodynamics
  • CFD dynamics as it relates to Chiari and syringomyelia
  • Fluid dynamics of blood and its relationship to disease


Selected Publications

B.A. Martin, F. Loth, “The influence of coughing on cerebrospinal fluid pressure in an in vitro syringomyelia model with spinal subarachnoid space stenosis” Cerebrospinal Fluid Research, 2009, Dec 31;6:17.

B.A. Martin, R. Labuda, T.J. Royston, J.N. Oshinski, B. Iskandar, F. Loth, “Spinal Canal Pressure Measurements in an In Vitro Spinal Stenosis Model: Implications on Syringomyelia Theories” Journal of Biomechanical Engineering, doi:10.1115/1.4000089, 2009.

W. Kalata, B.A. Martin, F. Loth, T.J. Royston, J.N. Oshinski, M. Jerosch-Herold, “MR Measurement of Cerebrospinal Fluid Wave Speed in the Spinal Subarachnoid Space,” IEEE Transactions on Biomedical Engineering, Vol. 56, No. 6, pp. 1765-8, June 2009.

Ford, M.D., Nikolov, H.N., Milner, J.S., Lownie, S.P., Demont, E.M., Kalata, W., Loth, F., Holdsworth, D.W., and Steinman, D.A., 2008, “PIV-Measured Versus Cfd-Predicted Flow Dynamics in Anatomically Realistic Cerebral Aneurysm Models,” Vol. 130, No. 2, pp. 021015, Journal of Biomechanical Engineering, April 2008.

S.E. Lee, S.W. Lee, P.F. Fischer, H.S. Bassiouny, F. Loth, “Direct numerical simulation of transitional flow in a stenosed carotid bifurcation,” Vol. 41, No. 11, pp. 2551-61, Journal of Biomechanics, 2008.
F. Loth, P.F. Fischer, H.S. Bassiouny, “Blood Flow in Anastomoses,” Annual Review of Fluid Mechanics, Vol. 50, pp. 367-393, Annual Review of Fluid Mechanics, January 2008.

P.F. Fischer, F. Loth, S.E. Lee, S.W. Lee, D.S. Smith, H.S. Bassiouny, “Simulation of High-Reynolds Number Vascular Flows,” Vol. 196, pp. 3049-3060, International Journal Computer Methods in Applied Mechanics and Engineering (CMAME), June 2007.

S.W. Lee, D.S. Smith, F. Loth, P.F. Fischer, H.S. Bassiouny, “Experimental and Numerical Simulation of Transitional Flow in a Blood Vessel Junction,” Vol. 51, No. 1, pp. 1-22, Numerical Heat Transfer: Part A, January, 2007.

S.W. Lee, D.S. Smith, F. Loth, P.F. Fischer, H.S. Bassiouny, “Importance of flow division on transition to turbulence within an arteriovenous graft ,” Vol. 40, No. 5, pp. 981-992, Journal of Biomechanics, 2007.
J.N. Oshinski, J.L. Curtin, F. Loth, “Mean-Average wall shear stress measurements in the common carotid artery,” Vol. 8, No 3, Journal of Cardiovascular Magnetic Resonance, July 2006.

F. Loth, M.A. Yardimci, N. Alperin, “Dynamics of cerebrospinal fluid in the spinal cavity,” Journal of Biomechanical Engineering, Vol. 123, No. 1, pp. 71-79, Feb. 2001.

N. Alperin, K. Kulkarni, F. Loth, B. Roitberg, M. Foroohar, M.F. Mafee, T. Lichtor, “Analysis of magnetic resonance imaging-based blood and cerebrospinal fluid flow measurements in patients with Chiari I malformation: A system approach,” Neurosurgical Focus, Vol. 11, No. 1, Article 6, pp. 1-10, July 2001.