Project Description

Many neurological conditions, such as MS, have been shown to involve significant changes in brain metabolism with indications of an inflammatory response.

Dr. Leah Shriver, a professor in the Department of Chemistry and Biology at the University of Akron, will use a $60,000 grant to explore her hypothesis that Chiari patients, due to the tonsillar herniation and disrupted flow of cerebrospinal fluid (CSF) will show significant alterations in the metabolic profile associated with the central nervous system.

Dr. Shriver is an expert in metabolomics and has studied the metabolic response associated with MS. Dr. Shriver believes that characterizing the metabolic response of CM patients will provide insights into the fundamental understanding of Chiari and also may provide an indicator of Chiari related pain.